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Can You Take Zofran While Pregnant?

Can You Take Zofran While Pregnant?
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The Risks and Benefits of Zofran for Pregnant Women


Zofran is a medication that is commonly used to treat nausea and vomiting in patients undergoing chemotherapy or surgery. However, some pregnant women may also experience morning sickness and may wonder if Zofran is safe to use during pregnancy. In this article, we will explore the risks and benefits of using Zofran while pregnant.

What is Zofran?

Zofran, also known as ondansetron, is a medication that belongs to a class of drugs called serotonin 5-HT3 receptor antagonists. It works by blocking the action of serotonin, a chemical in the body that can trigger nausea and vomiting.

Can You Take Zofran While Pregnant?

The use of Zofran during pregnancy is a controversial topic. The drug is not approved by the FDA for use in pregnant women, and some studies have suggested that it may increase the risk of birth defects. However, other studies have found no such link.

The Risks of Zofran During Pregnancy

One of the main concerns with using Zofran during pregnancy is the potential for birth defects. Some studies have suggested that Zofran may increase the risk of cleft palate, heart defects, and other birth defects. However, these studies have been criticized for their small sample sizes and other methodological flaws.

The Benefits of Zofran During Pregnancy

Despite the potential risks, many doctors still prescribe Zofran to pregnant women who are experiencing severe nausea and vomiting. This is because the benefits of the drug may outweigh the risks in certain cases. Severe morning sickness can lead to dehydration and weight loss, which can be harmful to both the mother and the baby.

Alternatives to Zofran During Pregnancy

If you are pregnant and experiencing morning sickness, there are several alternatives to Zofran that you may want to consider. These include natural remedies such as ginger, acupressure, and dietary changes. Your doctor may also be able to prescribe other medications that are considered safer during pregnancy.


The decision to use Zofran during pregnancy is a complex one that should be made in consultation with your doctor. While the drug may carry some risks, it can also be a lifesaver for pregnant women who are experiencing severe morning sickness. Ultimately, the best course of action will depend on your individual situation and medical history.


– “Ondansetron Use in Early Pregnancy and the Risk of Congenital Malformations: A Register-Based Nationwide Cohort Study.” JAMA Internal Medicine, 2016. – “The Safety of Ondansetron for Nausea and Vomiting of Pregnancy: A Prospective Comparative Study.” American Journal of Obstetrics and Gynecology, 2014. – “Morning Sickness: Nausea and Vomiting of Pregnancy.” American Family Physician, 2014.

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