Information for Health Care | Health News 2023

Zoloft And Weight Gain: What You Need To Know

Zoloft And Weight Gain: What You Need To Know
Zoloft (Sertraline) Drug Information


Since its introduction in 1991, Zoloft (sertraline) has become one of the most commonly prescribed antidepressants in the United States. While it is generally considered safe and effective, one side effect that has been reported by some users is weight gain.

How Zoloft Works

Zoloft is a selective serotonin reuptake inhibitor (SSRI), which means it works by increasing the levels of serotonin in the brain. Serotonin is a neurotransmitter that is involved in regulating mood, appetite, and sleep. By increasing serotonin levels, Zoloft can help alleviate symptoms of depression and anxiety.

Why Zoloft Can Cause Weight Gain

While the exact mechanism behind Zoloft-related weight gain is not fully understood, there are several theories. One possibility is that Zoloft may increase appetite or cravings for certain types of foods, leading to overeating and weight gain. Another theory is that Zoloft may slow down metabolism, making it harder for the body to burn calories.

The Evidence on Zoloft and Weight Gain

Studies have shown that weight gain is a possible side effect of Zoloft. In one study, nearly 30% of participants taking Zoloft for depression or anxiety reported gaining weight. However, it is important to note that not all users will experience weight gain and the amount of weight gained can vary widely.

What You Can Do

If you are taking Zoloft and are concerned about weight gain, there are several things you can do. First, talk to your doctor about your concerns. They may be able to adjust your dosage or switch you to a different medication. Additionally, making healthy lifestyle choices such as eating a balanced diet and getting regular exercise can help prevent weight gain.


Zoloft is a widely used medication that can be effective in treating depression and anxiety. However, weight gain is a potential side effect that should be taken into consideration. By being aware of the risks and taking steps to prevent weight gain, you can continue to enjoy the benefits of Zoloft while minimizing any unwanted side effects.


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